DNA gyrase, an enzyme unique to prokaryotes, has been implicated in almost all processes that involve DNA. Although efficient inhibitors of this protein have been known for more than 20 years, none of them have enjoyed prolonged pharmaceutical success. It is only recently that the mechanisms of inhibition for some of these classes of drugs have been established unequivocally by X‐ray crystallography. It is hoped that this detailed structural information will assist the design of novel, effective inhibitors of DNA gyrase.

Thomas Jefferson and Philosophy: Essays on the Philosophical Cast of Jefferson’s Writings is a collection of essays on topics that relate to philosophical aspects of Jefferson’s thinking over the years. Much historical insight is given to ground the various philosophical strands in Jefferson’s thought and writing on topics such as political philosophy, moral philosophy, slavery, republicanism, wall of separation, liberty, educational philosophy, and architecture.

Endosex, in contrast to intersex, refers to innate physical sex characteristics judged to fall within the broad range of what is considered normative or typical for ‘binary’ female or male bodies by the medical field, or to persons with such characteristics1 (p. 437). In this short contribution, we explain the origins and increasing use of this little-known term and discuss its practical and ethical relevance to medicine as well as to scholarship from a range of disciplines concerned with individuals’ sexed (...) embodiment. There is growing awareness in many quarters of the term intersex— used within some discourses to refer to clusters of bodily attributes (as in ‘intersex traits’, also termed differences of sex development or variations of sex characteristics)1 or more broadly to persons (as in ‘intersex persons’) whose bodily attributes differ from the dominant clinical, biological, or legal paradigms that categorise and differentiate female and male bodies. Intersex traits have historically been stigmatised as monstrous, morbid or tragic, justifying surgical and hormonal ‘fixing’.2 Persons born with the attributes named with these terms, even if physically healthy, therefore risk unnecessary pathologisation and medicalisation, prompting interventions, often non-voluntary, into their bodies to make them appear or function in ways that are deemed more typically female or male. In addition, some legal and social systems automatically associate persons with these traits with third categories of sex—neither female nor male—which may or may not align with their sex designation at birth, sex of rearing, personal experience or self-conception (see Coda). Being seen as intersex or being judged to have …. (shrink)

First published in 1894, this book consists of essays by professors Jowett and Campbell about the classic Greek philosopher Plato, and his famous and widely read dialogue The Republic, which is considered one the world's most influential works. Plato is believed to be the pivotal figure in the development of Western philosophy, and the editors explore this throughout the book along with relations to other Greek dialogues and authors.

In lieu of an abstract, here is a brief excerpt of the content:Hypermediated Art CriticismPamela G. Taylor (bio) and B. Stephen Carpenter II (bio)Technological media catapults our perception into what Marshall McLuhan called "new transforming vision and awareness."1 As our lives become more and more immersed in such technologies as television, film, and interactive computers, we find ourselves inundated with a heightened sense of mindfulness—an aesthetic experience made possible through such computer technological characteristics as hyperlinks, hypermedia, and hyperreality. In (...) these terms, the prefix "hyper" represents various linking devices inherent to computer technology that allure and transport us between, above, below, and toward vast areas of information, places, and peoples. Hypermediacy, according to Bob Cotton and Richard Oliver, is "an entirely new kind of media experience born from the marriage of TV and computer technologies. Its raw ingredients can be brought together in any combination. It is a medium that offers random access; it has no physical beginning, middle, or end."2 In other words, there is no set or static structure inherent in technological media. It is not so much an "anything goes" apparatus as it is an "anything is possible" system. The seemingly vast possibilities inherent to technological media offer us many and alternate views of the world.Just as technological media encourage multiple means of viewing the world, no single approach to art criticism can be considered dominant, as several methods, methodologies, and approaches exist for responding to [End Page 1] works of art. We conceive of art criticism as a complex means of making meanings about works of art and communicating those meanings to other people. Following the lead of art educator Terry Barrett,3 art criticism hinges on the four activities of describing, interpreting, judging, and theorizing about art. Barrett suggests that, although all four overlap, interpretation is the most important and most likely the most complex aspect of art criticism. Although interwoven with description, analysis, and judgment, interpretation of the meanings of individual works of art is of foremost concern in contemporary art criticism. Similarly, we situate hypermediated art criticism as a synthesis of our descriptions, interpretations, judgments, and theories—both verbal and visual—with the various ways in which computer technology facilitates the simultaneous existence, representation, storage, and presentation of these and other forms of meaning making about works of art.Hypermediated art criticism is built upon our own technological abilities to both create and follow divergent paths, ideas, and beliefs according to our choices. Hypermediated art criticism is inclusive of the ways that our choices change daily depending upon our situation, role, and purpose, or simply as a result of what we witness or experience in a moment. In the hypermediated criticism process, our ways of seeing and knowing change from a linear to multilinear perspective, from single to multilayered, and from static to mutable perception. Indeed, the disparate ways of seeing and knowing made possible through technological media and hypermedia provide us with an expansive and personally reflective approach to art criticism.Personal Reflection and Art CriticismMichael Joyce, known for his poetic approach to computer hypertext theory and fictional writing, says, "We are who we are. Layered and overlaid, we make a world within our bodies."4 Possibly now more than ever that world within our bodies can be represented, re-presented, and re-invented right before our eyes through technological media. Digital ethnographer Ricki Goldman-Segall refers to this technological world as a learning constellation in which "we are each composed of many selves, all of which interact with each other as we learn.... With the use of new computer technologies, we extend not only our technological abilities, but also our various personae—the societies of our minds—in the form of new objects for others to think with."5 In the classroom, hypermediated art criticism generated through computer technology functions just this way—as new objects that we, and our students, use to help us extend the ways in which we think about works of art.Contrary to the antihumanist approach so often associated with computer technology theory,6 our discussion of hypermediated art criticism—the symbiotic relationship of art criticism and technology—begins with the [End Page 2] basic assumption that a primary purpose of... (shrink)

The authors respond to a letter by Mitchell Berger in the March‐April 2024 issue of the Hastings Center Report concerning their essay “Securing the Trustworthiness of the FDA to Build Public Trust in Vaccines.”.

Important features of the self-concept can be located outside of the individual and inside close or related others. The authors use this insight to reinterpret data previously said to support the empathy-altruism model of helping, which asserts that empathic concern for another results in selflessness and true altruism. That is, they argue that the conditions that lead to empathic concern also lead to a greater sense of self-other overlap, raising the possibility that helping under these conditions is not selfless but (...) is also directed toward the self. In 3 studies, the impact of empathic concern on willingness to help was eliminated when oneness--a measure of perceived self-other overlap--was considered. Path analyses revealed further that empathic concern increased helping only through its relation to perceived oneness, thereby throwing the empathy-altruism model into question. The authors suggest that empathic concern affects helping primarily as an emotional signal of oneness. (shrink)

Researchers are beginning to transition from studying human–automation interaction to human–autonomy teaming. This distinction has been highlighted in recent literature, and theoretical reasons why the psychological experience of humans interacting with autonomy may vary and affect subsequent collaboration outcomes are beginning to emerge (de Visser et al., 2018;Wynne and Lyons, 2018). In this review, we do a deep dive into human–autonomy teams (HATs) by explaining the differences between automation and autonomy and by reviewing the domain of human–human teaming to make (...) inferences for HATs. We examine the domain of human–human teaming to extrapolate a few core factors that could have relevance for HATs. Notably, these factors involve critical social elements within teams that are central (as argued in this review) for HATs. We conclude by highlighting some research gaps that researchers should strive toward answering, which will ultimately facilitate a more nuanced and complete understanding of HATs in a variety of real-world contexts. (shrink)

This study examined how sales managers react to ethical and unethical acts by their salespeople. Deontological considerations and, to a much lesser extent, teleological considerations predicted sales managers' ethical judgments. Sales managers' intentions to reward or discipline ethical or unethical sales force behavior were primarily determined by their ethical judgments. An organization's perceived ethical work climate was not a significant predictor of sales managers' intentions to intervene when ethical and unethical sales force behavior was encountered.

The third edition of the Standards for Academic and Professional Instruction in Foundations of Education, Educational Studies, and Educational Policy Studies (Standards) challenge us to envision what ?a more holistic, inclusive and intellectually challenging approach to preparing educators? might look like. This article discusses how the operating principles of a teacher education program parallel the commitments for educators found in the Standards and explores why collaborative relationships between teacher education and social foundations matter. Given the current political and social climate (...) surrounding the field of education, it is important for those of us in the field of social foundations to think outside the box. (shrink)

In those twenty or so pages of section xi of Part Two of the Philosophical Investigations in which Wittgenstein discusses the concept of noticing an aspect and its place among the concepts of experience, there are three passages which are explicitly concerned with the relations between seeing and interpreting in the experience of noticing an aspect.

The Covid‐19 pandemic highlighted the need to examine public trust in the U.S. Food and Drug Administration (FDA) vaccine approval process and the role of political influence in the FDA's decisions. Ensuring that the FDA is itself trustworthy is important for justifying public trust in its actions, like vaccine approvals, thereby promoting public health. We propose five conditions of trustworthiness that the FDA should meet when it reviews vaccines, even during emergencies: consistency with rules, proper expert or political decision‐makers, proper (...) decision‐making and noninterference, connection to public preference, and transparency of both reasons and procedures. The five conditions provide a road map of procedural and substantive requirements, which the FDA has variably implemented, focused on ensuring appropriate influence of political interests. While being a trustworthy agency cannot guarantee the public's trust, implementing these conditions builds a groundwork for public trust. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Wittgenstein, Tolstoy, and ShakespearePeter B. LewisNear the middle of the first of his 1938 Lectures on Aesthetics, Wittgenstein talks about what he calls "the tremendous things in art"(LC, I 23 8, italics in original).1 Apart from a brief indication of the way in which our response to the tremendous differs from the non-tremendous, he does not refer again in this way to the tremendous things in art, though he (...) does refer elsewhere to what he calls "supreme art." But he does provide a couple of examples of the tremendous in art, the symphonies of Beethoven and Gothic Cathedrals. Suppose, now, like the student in the Investigations §185, we are asked to continue the series. I take it that, even given the lack of information, we could safely propose, say, Homer—the Iliad and the Odyssey—and Michelangelo—the Sistine Chapel—as further examples of the tremendous things in art. The idea is that the tremendous things in art are not works that are just very good or very fine, but rather they are great, supremely great; works of stature; special cases; instances of the highest kind of artistic achievement, occupying a distinctive place in the history of (Western) civilization.Another obvious candidate for the list of the tremendous things in art would be Shakespeare, where the name is shorthand for the great plays, the tragedies in particular, Lear, Hamlet, Othello,and so on. So it comes as something of a surprise to discover on reading that miscellaneous compendium of remarks known as Culture and Value that Wittgenstein himself had serious doubts about including Shakespeare in the pantheon of the tremendous things in art. There are seven passages in Culture and Value in which Wittgenstein reflects on Shakespeare.2 The earliest is dated 1939–40, though this passage does not appear to be critical of Shakespeare. The next two passages are [End Page 241] dated August 1946, the remainder coming in 1949 and 1950. The remarks critical of Shakespeare are, then, all very much late Wittgenstein.It is well-known that lots of people dislike Shakespeare's plays. Generations of school children have developed indifference or boredom or hatred that persists throughout their lives. And yet that does not count against Shakespeare's greatness; for, to borrow Hume's remark on those who would prefer Ogilby to Milton, "no one pays attention to such a taste; and we pronounce without scruple the sentiment of these [people] to be absurd and ridiculous."3 That rhetoric is, however, not available, at least not immediately, when the "pretended critic" (Hume's phrase) has the intellectual clout and aesthetic sensibility of a Wittgenstein; nor, for that matter, the artistic achievement of a Tolstoy.I have particular grounds for bringing Tolstoy into this discussion. In the first place, there is the importance of Tolstoy in the development of Wittgenstein's thinking about religious, moral and aesthetic issues. Secondly, it is by contrast with Tolstoy's criticism of Shakespeare that we can gain further understanding of Wittgenstein's remarks on Shakespeare. These two points are related. For it seems to me that it is partly through his reflections on Tolstoy's theories about art that Wittgenstein is led into commenting upon Shakespeare.Tolstoy famously attacks Shakespeare in his pamphlet, "Shakespeare and the Drama,"4 published in 1903 when Tolstoy was seventy-five years of age. Some have taken this essay as evidence that Tolstoy was in his dotage, his mind warped by religious-moralistic fervor. Not only does this fail to do justice to Tolstoy's reasons for criticizing Shakespeare—reasons that Howard Mounce has recently argued are by no means ridiculous5 —it also neglects the fact that the essay is the culmination of Tolstoy's life-long antagonism to Shakespeare. Nevertheless, that very slur on Tolstoy's sanity attests to Shakespeare's status in our culture as something tremendous. His achievement is a standard against which others are measured. And this, I think, is at least partly what Wittgenstein is hinting at in his remarks about the contrast between the tremendous and the non-tremendous in art when he says of the tremendous that "it plays an entirely different role... (shrink)